This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Fluconazole and voriconazole slow down how quickly your liver processes certain non-steroidal anti-inflammatory medicines (NSAIDs).
What might happen:
The amount of the NSAID in your body may increase. This may increase your risk of having side effects from these medicines.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Your doctor may want to monitor you more closely or may want to lower the dose of your NSAID while you are taking fluconazole or voriconazole.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.US Food and Drug Administration (FDA). Drug Development and Drug Interactions: Table of Substrates, Inhibitors and Inducers. Available at: http://www.fda.gov/Drugs/DevelopmentApprovalProcess/DevelopmentResources/D rugInteractionsLabeling/ucm093664.htm. Updated 08/05/2011.
2.Celebrex (celecoxib) US prescribing information. Pfizer Inc. February 4, 2011.
3.Mobic (meloxicam) US prescribing information. Boehringer Ingelheim March 5, 2012.
4.Cataflam (diclofenac potassium) US prescribing information. Novartis Pharmaceuticals February, 2011.
5.Feldene (piroxicam) US prescribing information. Pfizer Inc. August 13, 2010.
6.Dynastat (parecoxib) UK summary of product characteristics. Pfizer Limited February 7, 2012.
7.Vfend (voriconazole) US prescribing information. Pfizer Inc. November, 2011.
8.Diflucan (fluconazole) US prescribing information. Pfizer Inc. November, 2011.