Protein C is a natural substance in your body that helps to decrease clotting in the blood vessels. This medication is used to prevent and treat blood clots (e.g., venous thrombosis, purpura fulminans) in people who are born with a severe lack of protein C.
Read the Patient Information Leaflet provided by your pharmacist before you start using protein C concentrate and each time you get a refill. If you have any questions, consult your doctor or pharmacist.
This medication is given by injection into a vein as directed by your doctor. Dosage is based on your medical condition, age, weight, protein C level, and response to treatment.
Use this medication regularly to get the most benefit from it. To help you remember, use it at the same times each day.
Tell your doctor if your condition persists or worsens.
Lightheadedness may occur. If this effect persists or worsens, tell your doctor or pharmacist promptly.
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Tell your doctor right away if you have any serious side effects, including: easy or unusual bruising/bleeding, signs of infection (e.g., fever, chills), signs of liver disease (e.g., dark urine, yellowing eyes/skin, persistent nausea/vomiting, severe stomach/abdominal pain).
A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, chest pain, shortness of breath, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact the doctor.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Before using protein C concentrate, tell your doctor or pharmacist if you are allergic to it; or to heparin; or to mouse protein; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, low platelet counts after heparin treatment.
This medication contains sodium. Consult your doctor or pharmacist if you are on a salt-restricted diet or if you have a condition that could be worsened by an increase in salt intake (e.g., heart failure, high blood pressure).
Before having surgery, tell your doctor that you are using this medication.
This medication is made from human blood. Even though the blood is carefully tested and this medication goes through a special manufacturing process, there is an extremely small chance that you may get infections from the medication (e.g., virus infections such as hepatitis). Consult your doctor or pharmacist for more information, and ask whether you should get vaccinations before receiving this medication.
During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.
It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding.
Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.
Some products that may interact with this drug include: anti-platelet medications (e.g., clopidogrel, NSAIDs such as aspirin/ibuprofen), "blood thinners" (e.g., enoxaparin, heparin, warfarin), clot-dissolving drugs (e.g., thrombolytics such as alteplase).
If your doctor has prescribed low doses of aspirin to prevent heart attack or stroke (usually at dosages of 81-325 milligrams a day), you should continue to take the aspirin. Consult your doctor or pharmacist for more details.
If overdose is suspected, contact a poison control center or emergency room right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.
Laboratory and/or medical tests (e.g., protein C activity/levels) should be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.
For the best possible benefit, it is important to receive each scheduled dose of this medication as directed. If you miss a dose, contact your doctor or pharmacist right away to establish a new dosing schedule.
Not applicable. This medication is given in a clinic and will not be stored at home.
Information last revised October 2015. Copyright(c) 2015 First Databank, Inc.
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