This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Rifampin may speed up how quickly your liver processes efavirenz and raltegravir.
What might happen:
The amount of efavirenz or raltegravir in your blood may decrease and it may not work as well.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Your doctor may want to run some blood tests to check how your medicine is working. Your doctor may want to change the dose of your efavirenz or raltegravir while you are taking rifampin.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Sustiva (efavirenz) US prescribing information. Bristol-Myers Squibb Company March, 2015.
2.Isentress (raltegravir) Australian prescribing information. Merck Sharp & Dohme PTY Limited May 19, 2008.
3.Isentress (raltegravir) US prescribing information. Merck & CO., Inc. February, 2015.
4.Isentress (raltegravir) Canadian prescribing information. Merck Frosst February 18, 2009.
5.Isentress (raltegravir) UK summary of product characteristics. Merck Sharp & Dohme Limited August 3, 2013.