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etravirine

Interactions

Etravirine; Nevirapine/Rifampin; Rifapentine

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Severe. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Rifampin and rifapentine may speed up how quickly your liver processes etravirine or nevirapine.

What might happen:

The amount of etravirine or nevirapine in your blood may decrease and it may not work as well against your HIV infection.

What you should do about this interaction:

Contact your healthcare professional (e.g. doctor or pharmacist) right away about taking these medicines together. Your doctor may want to change your antibiotic.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

References:

1.Intelence (etravirine) US prescribing information. Tibotec, Inc. February, 2013.

2.Viramune (nevirapine) Australian prescribing information. Boehringer Ingelheim Pty Ltd. October 24, 2003.

3.Viramune (nevirapine) UK summary of product characteristics. Boehringer Ingelheim Limited April, 2007.

4.Viramune (nevirapine) US prescribing information. Boehringer Ingelheim Pharmaceuticals, Inc. January, 2014.

5.Viramune (nevirapine) Canadian prescribing information. Boehringer Ingelheim 2002.

6.Ribera E, Pou L, Lopez RM, Crespo M, Falco V, Ocana I, Ruiz I, Pahissa A. Pharmacokinetic interaction between nevirapine and rifampicin in HIV-infected patients with tuberculosis. J Acquir Immune Defic Syndr 2001 Dec 15;28(5):450-3.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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