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    Oral Quinolones/Aluminum; Lanthanum; Magnesium (mono deleted 12/01/2011)

    This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

    Medical warning:

    Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

    How the interaction occurs:

    When these two medicines are taken together, the aluminum and/or magnesium in the antacid or Videx chewable/dispersible tablet or your lanthanum may bind to your antibiotic. This prevents your body from absorbing the antibiotic.

    What might happen:

    The blood levels of your antibiotic may be decreased, which will decrease the effectiveness in treating your infection.

    What you should do about this interaction:

    You should time when you take your antibiotic and your antacid or Videx chewable/dispersible tablets (which contain magnesium) so that you do not these medicines: --within 6 hours before or 2 hours after ciprofloxacin --within 8 hours before or 2 hours after enoxacin --until 4 hours after gatifloxacin --within 3 hours before or 2 hours after gemifloxacin --within 2 hours before or 2 hours after levofloxacin --within 4 hours before or 2 hours after lomefloxacin --within 8 hours before or 4 hours after moxifloxacin --within 2 hours before or after nalidixic acid --within 2 hours before or 2 hours after norfloxacin --within 2 hours before or 2 hours after ofloxacin --until 4 hours after sparfloxacin --within 2 hours before or 2 hours after trovafloxacin.If you are taking lanthanum, your doctor may tell you to follow the above timing instructions, or to time your lanthanum so that you take your antibiotic at least 1 hour before your lanthanum or 4 hours after it, or to skip doses that you would normally take at the same time as your antibiotic.If you are not sure which antibiotic you are on or if you have questions about the timing of doses of your medicine, contact your healthcare professionals (e.g. doctor or pharmacist). They may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.


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    2.Cipro (ciprofloxacin hydrochloride) US prescribing information. Bayer Corporation February, 2011.

    3.Penetrex (enoxacin) US prescribing information. Aventis Pharmaceuticals, Inc. July, 1998.

    4.Tequin (gatifloxacin) US prescribing information. Bristol-Myers Squibb Company January, 2006.

    5.Factive (gemifloxacin mesylate) US prescribing information. Oscient Pharmaceuticals February, 2011.

    6.Levaquin (levofloxacin) US prescribing information. Ortho-McNeil Pharmaceutical, Inc. February, 2011.

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    12.Zagam (sparfloxacin) US prescribing information. Bertek Pharmaceuticals, Inc. February, 2003.

    13.Trovan (trovafloxacin mesylate) US prescribing information. Roerig April, 2000.

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    40.Vinceneux P, Weber P, Gaudin H, Boussougant Y. Decreased absorption of pefloxacin by gastric antacids. Preliminary study. Presse Med 1986 Oct 18;15(36):1826.

    Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

    CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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