Severe. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
When these two medicines are taken together, your body may not process cisapride properly.
What might happen:
Your blood levels of cisapride may increase and cause life-threatening effects to your heart.
What you should do about this interaction:
Contact your healthcare professionals (e.g. doctor or pharmacist) as soon as possible about taking these two medicines together. They may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Serzone (nefazodone hydrochloride) US prescribing information. Bristol-Myers Squibb Company January, 2005.
2.Prepulsid (cisapride) US prescribing information. Janssen Pharmaceutica Products, L.P. January, 2000.
3.Fluvoxamine maleate US prescribing information. Eon Labs, Inc. March, 2005.
4.Prozac (fluoxetine hydrochloride) US prescribing information. Eli Lilly and Company January, 2013.
5.Paxil (paroxetine hydrochloride) US prescribing information. GlaxoSmithKline December, 2012.
6.Pexeva (paroxetine mesylate) US prescribing information. Noven Therapeutics, LLC December, 2012.
7.Zoloft (sertraline) US prescribing information. Pfizer Inc. December, 2012.
8.Drew BJ, Ackerman MJ, Funk M, Gibler WB, Kligfield P, Menon V, Philippides GJ, Roden DM, Zareba W. Prevention of torsade de pointes in hospital settings: a scientific statement from the American Heart Association and the American College of Cardiology Foundation. J Am Coll Cardiol 2010 Mar 2;55(9):934-47.