Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Dabrafenib may speed up how quickly your liver processes hormonal contraceptive agents.
What might happen:
Hormonal contraceptive products (such as "the pill", the "mini-pill", Norplant, birth control injections, and the patch) may not prevent you from becoming pregnant while you are taking dabrafenib. If you take dabrafenib while pregnant, it may cause birth defects or a miscarriage.
What you should do about this interaction:
You should not rely on a hormonal contraceptive agent as your only method of birth control while taking dabrafenib, for two weeks after stopping dabrafenib, or for four months after stopping combination therapy with dabrafenib and trametinib. Discuss birth control options with the doctor that prescribed dabrafenib for you and/or with your gynecologist (OB/GYN). If you think that you may be pregnant, contact your doctor right away.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.Reference:1.Tafinlar (dabrafenib) US prescribing information. GlaxoSmithKline January, 2014.