Skip to content


    Side Effects

    List tapentadol side effects by likelihood and severity.

    The following side effects are associated with tapentadol:

    Common side effects of tapentadol:

    • Abnormally Low Blood PressureSevere
    • DizzyLess Severe
    • DrowsinessLess Severe
    • Dry MouthLess Severe
    • Feel Like Throwing UpLess Severe
    • Head PainLess Severe
    • Incomplete or Infrequent Bowel MovementsLess Severe
    • Low EnergyLess Severe
    • Throwing UpLess Severe

    Infrequent side effects of tapentadol:

    • ItchingSevere
    • Abnormal DreamsLess Severe
    • AnxiousLess Severe
    • Blurred VisionLess Severe
    • ChillsLess Severe
    • Chronic Trouble SleepingLess Severe
    • DepressionLess Severe
    • Disturbance of AttentionLess Severe
    • Excessive SweatingLess Severe
    • Inability to have an ErectionLess Severe
    • IndigestionLess Severe
    • Involuntary QuiveringLess Severe
    • Sensation of Spinning or WhirlingLess Severe
    • SluggishnessLess Severe
    • Temporary Redness of Face and NeckLess Severe

    Rare side effects of tapentadol:

    • Abnormal Nervous System Function Affecting Mental AlertnessSevere
    • Adrenal Gland ProblemsSevere
    • ConfusedSevere
    • Decreased Lung FunctionSevere
    • Decreased Motility Function of Stomach or IntestinesSevere
    • Giant HivesSevere
    • Having Thoughts of SuicideSevere
    • Heart Throbbing or PoundingSevere
    • High Pressure Within the SkullSevere
    • HivesSevere
    • Life Threatening Allergic ReactionSevere
    • Panic DisorderSevere
    • RashSevere
    • SeizuresSevere
    • Serotonin Syndrome - Adverse Drug InteractionSevere
    • Severely Low Blood PressureSevere
    • Spasm of a Bile Duct TractSevere
    • Trouble BreathingSevere
    • Altered Interest in Having Sexual IntercourseLess Severe
    • Cannot Empty BladderLess Severe
    • DiarrheaLess Severe
    • Difficulty SpeakingLess Severe
    • Easily Angered or AnnoyedLess Severe
    • Extreme Sense of Well BeingLess Severe
    • Feeling FaintLess Severe
    • Feeling RestlessLess Severe
    • Frequent UrinationLess Severe
    • HallucinationLess Severe
    • Inducing of a Relaxed Easy StateLess Severe
    • Loss of MemoryLess Severe
    • NumbnessLess Severe
    • Numbness and TinglingLess Severe
    • Problems Getting PregnantLess Severe
    • Problems with EyesightLess Severe
    • Stomach CrampsLess Severe
    • UncoordinatedLess Severe
    • Weight LossLess Severe

    Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

    CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

    More about Drugs and Medications


    Subscribe to free WebMD newsletters.

    • WebMD Daily

      WebMD Daily

      Subscribe to the WebMD Daily, and you'll get today's top health news and trending topics, and the latest and best information from WebMD.

    • Men's Health

      Men's Health

      Subscribe to the Men's Health newsletter for the latest on disease prevention, fitness, sex, nutrition, and more from WebMD.

    • Women's Health

      Women's Health

      Subscribe to the Women's Health newsletter for the latest on disease prevention, fitness, sex, diet, anti-aging, and more from WebMD.

    By clicking Submit, I agree to the WebMD Terms & Conditions & Privacy Policy and understand that I may opt out of WebMD subscriptions at any time.

    URAC: Accredited Health Web Site TRUSTe Privacy Certification HONcode Seal AdChoices