If you are:
Only When Necessary: INSUFFICIENT HUMAN DATA AVAILABLE; DEVELOPMENTAL TOXICITY SEEN IN ANIMALS W/MRHD
Precaution: INSUFF HUMAN DATA AVAIL; MOLECULAR WEIGHT LOW; EXCRETION POSSIBLE
An adult over 60:
management or monitoring precaution: Renal-Establish creatinine clearance prior to treatment. Dalfampridine is contraindicated for CrCL< 50 mL/min. due to drug accumulation. Neuro/Psych-Seizure risk increases with lower CrCL.
Giving dalfampridine Tablet, Extended Release 12 hr to a child under 12:
management or monitoring precaution: Safety and efficacy not established.