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Sandimmune intravenous

Interactions

Cyclosporine/Amphotericin B

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

When these two medicines are taken together, the potential toxic effects on your kidney may be increased.

What might happen:

Your blood levels of cyclosporine may increase and cause kidney damage.

What you should do about this interaction:

If your doctor prescribes these medicines together, you may need to have blood levels of cyclosporine and kidney tests more regularly monitored. Your doctor may need to adjust the dose of your cyclosporine.Contact your healthcare professionals (e.g. doctor or pharmacist) as soon as possible about taking these two medicines together. They may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

References:

1.Kennedy MS, Deeg HJ, Storb R. Cyclosporin A: clinical pharmacologic aspects of a novel immunosuppressant. Clin Res 1981;29(2):273a.

2.Kennedy MS, Deeg HJ, Siegel M, Crowley JJ, Storb R, Thomas ED. Acute renal toxicity with combined use of amphotericin B and cyclosporine after marrow transplantation. Transplantation 1983 Mar;35(3):211-5.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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