Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Nevirapine increases how quickly your body processes your antifungal medicine. Ketoconazole may decrease how quickly your body processes nevirapine.
What might happen:
When taken together, nevirapine may decrease the levels of antifungal medicine in your blood, making it less effective. If your antifungal medicine is ketoconazole, the amount of nevirapine in your blood may increase.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Your doctor may want to change your medicine, adjust the dose or check medicine levels in your blood.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Viramune (nevirapine) US prescribing information. Boehringer Ingelheim Pharmaceuticals, Inc. January, 2014.
2.Nizoral (ketoconazole oral) US prescribing information. Janssen Pharmaceuticals February, 2014.
3.Sporanox (itraconazole) US prescribing information. Janssen Pharmaceutica Products, L.P. April, 2015.
4.Department of Health and Human Services. Table 15b. Drug Interactions between Non-Nucleoside Reverse Transcriptase Inhibitors and Other Drugs. Guidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents 02/12/2013.