If you are:
Only When Necessary: INSUFFICIENT HUMAN DATA AVAILABLE; ANIMAL TOXICITY SEEN AT 4 TO14 TIMES MRHD
Precaution: INSUFFICIENT DATA AVAILABLE
An adult over 60:
management or monitoring precaution: Renal-Elderly have been shown to have increased serum drug concentrations and total exposure to the drug. Since this may lead to increased risk of toxicity including hemorrhage, assess renal function before initiating therapy. Evaluate closely for signs or symptoms of blood loss in patients with CrCl=30-50 mL/min. Avoid use if CrCL< 30 mL/min.
Giving Xarelto to a child under 12:
management or monitoring precaution: Safety and efficacy not established.