This medication is used to make the urine less acidic. Urine that is less acidic helps the kidneys get rid of uric acid, helping to prevent gout and certain types of kidney stones (urate). This medication can also prevent and treat certain metabolic problems (acidosis) caused by kidney disease.
Citric acid and citrate salts (which contain potassium and sodium) belong to a class of drugs known as urinary alkalinizers. Because some conditions require you to limit your intake of potassium and sodium, your doctor's choice of product may depend on how much potassium and sodium you can take.
Take this medication by mouth, usually 4 times a day or as directed by your doctor. To help prevent diarrhea, take each dose after a meal. To prevent stomach upset, mix your prescribed dose of medication in a full glass (4 to 8 ounces or 120 to 240 milliliters) of cold water or juice just before taking, or take as directed by your doctor. Drink the entire mixture slowly. If you still have stomach upset, mixing your dose in a larger amount of liquid may help unless your doctor directs you otherwise. Ask your doctor or pharmacist for further instructions.
Dosage is based on your medical condition and response to treatment. Carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose.
The liquid form of this medication must be mixed with at least 4 ounces (120 milliliters) of water or juice before taking.
Refrigerating the mixture before drinking may improve the taste. Drink more water or juice after taking this medication unless otherwise directed by your doctor.
Take this medication as prescribed. Do not increase your dose or take this more often without your doctor's approval. Use this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day.
While taking this medication, you may need to test the pH (acidity) of your urine using special paper. The pH will help determine the proper dose. Consult your doctor or pharmacist for more information.
Nausea, vomiting, diarrhea, and stomach pain may occur. Mixing the medication with water or juice, taking it after meals, and drinking more fluids will help prevent these side effects. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Tell your doctor right away if any of these unlikely but serious side effects occur: severe stomach/abdominal pain, swelling of the hands/ankles/feet, tingling/numbness of the hands/feet, weakness.
Tell your doctor right away if any of these rare but very serious side effects occur: fast/slow/irregular heartbeat, mental/mood changes (e.g., confusion, restlessness), muscle spasms, seizures, bloody/black/tarry stools, vomit that looks like coffee grounds.
A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Before taking this medication, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: underactive adrenal gland (Addison's disease), severe heart disease (e.g., recent heart attack, heart damage), severe kidney disease (e.g., unable to make urine), sodium- /potassium-restricted diet, high sodium/potassium levels, severe loss of body water (dehydration).
Before using this medication, tell your doctor or pharmacist your medical history, especially of: a certain breathing problem (pulmonary edema), low calcium levels, high blood pressure, heart problems (e.g., irregular heartbeat, heart failure), kidney disease, stomach/gut problems (e.g., peptic ulcers, irritable bowel), swollen ankles/legs/feet due to retaining water (peripheral edema).
Liquid forms of this product may contain sugar. Caution is advised if you have diabetes. Ask your doctor or pharmacist about using this product safely.
Because this medication contains salt (sodium), tell your doctor if you are on a salt-restricted diet.
During pregnancy, this medication should be used only when clearly needed. This medication may worsen high blood pressure during pregnancy (toxemia of pregnancy). Discuss the risks and benefits with your doctor.
It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding.
The effects of some drugs can change if you take other drugs or herbal products at the same time. This can increase your risk for serious side effects or may cause your medications not to work correctly. These drug interactions are possible, but do not always occur. Your doctor or pharmacist can often prevent or manage interactions by changing how you use your medications or by close monitoring.
To help your doctor and pharmacist give you the best care, be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products) before starting treatment with this product. While using this product, do not start, stop, or change the dosage of any other medicines you are using without your doctor's approval.
Some products that may interact with this drug include: antacids that contain aluminum, aspirin and other salicylates (e.g., salsalate), certain blood pressure medications (e.g., ACE inhibitors such as lisinopril, angiotensin blockers such as losartan), drospirenone, eplerenone, certain heart medications (e.g., quinidine, digoxin), lithium, potassium supplements, certain "water pills" (potassium-sparing diuretics such as amiloride, spironolactone, triamterene).
If your doctor has directed you to take low-dose aspirin for heart attack or stroke prevention (usually at dosages of 81-325 milligrams a day), you should continue taking it unless your doctor instructs you otherwise. Ask your doctor or pharmacist for more details.
This document does not contain all possible drug interactions. Keep a list of all the products you use. Share this list with your doctor and pharmacist to lessen your risk for serious medication problems.
If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: slow heartbeat, muscle spasms, seizures.
Do not share this medication with others.
Laboratory and/or medical tests (e.g., potassium/sodium levels) should be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.
If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.
Store at room temperature between 68 and 77 degrees F (20 and 25 degrees C) away from light and moisture. Do not store in the bathroom. Keep all medicines away from children and pets. Do not freeze. Protect from heat.
Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.
Information last revised July 2016. Copyright(c) 2016 First Databank, Inc.
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