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Drugs & Medications

deferiprone

COMMON BRAND NAME(S): Ferriprox

GENERIC NAME(S): DEFERIPRONE

WARNINGS:

This medication may rarely cause a very serious low white blood cell count, which increases your risk of serious, possibly fatal infections. To lower your risk, your doctor will check your blood counts with a blood test before and regularly during treatment. Get medical help right away if you develop any signs of infection such as fever, persistent sore throat, chills, or flu-like symptoms.

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Uses

This medication is used by people with a certain type of blood disorder (thalassemia) who have too much iron in the body, caused by repeated blood transfusions. Blood transfusions help people with blood disorders but they also bring extra iron into the body. It is important to get rid of the extra iron because high levels of iron can cause health problems (such as heart failure, liver disease, diabetes, delayed growth in children). Deferiprone is used if you have trouble taking other traditional iron-removal medications or you continue to have high iron levels after taking other iron-removal medications.

Deferiprone belongs to a class of drugs known as iron chelators. It works by attaching to iron which helps your body pass the extra iron out in the urine.

How to use deferiprone

Read the Medication Guide provided by your pharmacist before you start taking deferiprone and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth with or without food as directed by your doctor, usually 3 times a day (morning, midday, and evening). Taking this medication with food may help lessen nausea.

Take this medication 4 hours apart from products that may bind to it, decreasing its effectiveness. Ask your pharmacist about the other products you take. Some examples include antacids, vitamins/minerals (such as those containing iron, aluminum, zinc), among others.

The dosage is based on your medical condition, weight, and response to treatment (including laboratory test results). Your treatment may need to be adjusted or stopped if you develop serious side effects. Follow your doctor's instructions carefully. Keep all medical/laboratory appointments.

Take this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day.

Side Effects

See also Warning and How To Use sections.

Nausea, vomiting, stomach/abdominal pain, or joint pain may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

This medication may cause your urine to turn a reddish-brown color. This effect is harmless and will disappear when the medication is stopped.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing, bloody stools.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking deferiprone, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, liver disease, low white blood cell count.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

This medication is not recommended for use during pregnancy. It may harm an unborn baby. Discuss the risks and benefits with your doctor.

It is unknown if deferiprone passes into breast milk. Because of the possible risk to the infant, breast-feeding while using this medication is not recommended. Consult your doctor before breast-feeding.

Interactions

See also How To Use section.

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Overdose

If overdose is suspected, contact a poison control center or emergency room immediately. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: vision problems, weak muscles, unusual/slowed movements.

Notes

Do not share this medication with others.

Laboratory tests (such as liver function tests, complete blood counts, iron (ferritin) and zinc levels) should be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.

Missed Dose

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Storage

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Information last revised March 2013. Copyright(c) 2013 First Databank, Inc.

Images

FERRIPROX 500 MG TABLET
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FERRIPROX 500 MG TABLET

Identification

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This medicine is a white, oblong, scored, film-coated tablet imprinted with "APO 500".

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Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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