Aflibercept is used to treat certain serious eye conditions (wet age-related macular degeneration - wet AMD, macular edema following central retinal vein occlusion, diabetic macular edema). This medication can help preserve vision and prevent blindness. Aflibercept belongs to a class of drugs known as growth factor inhibitors. It works by slowing the growth of abnormal new blood vessels in the eye and decreasing leakage from these blood vessels.
This medication is prepared and given by injection into the affected eye(s) by a health care professional. The affected eye is numbed before each injection. After the injection, you will remain in the doctor's office for a while, and your eye(s) and vision will be monitored.
For wet AMD, this medication is usually given once a month for the first three months and then given once every two months.
For macular edema following central retinal vein occlusion, this medication is usually given once a month.
For diabetic macular edema, this medication is usually given once a month for the first five months and then given once every two months.
Use this medication regularly to get the most benefit from it.
Tell your doctor if your condition worsens.
Injection site pain, feeling as if something is in the eye, or increased tears may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Tell your doctor right away if you have any serious side effects, including: floaters (blurry shapes that seem to float in front of your eyes), swollen eyelids.
Get medical help right away if you have any very serious side effects, including: chest/jaw/left arm pain, shortness of breath, unusual sweating, weakness on one side of the body, slurred speech, confusion.
This medication may infrequently increase your risk for developing certain serious eye conditions (endophthalmitis or retinal detachment). Get medical help right away if you notice any of these symptoms in the affected eye(s): pain, redness, sensitivity to light, blurred vision, sudden change in vision, loss of vision.
A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US -
Before taking aflibercept, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: a current eye infection.
This drug may cause blurred vision. Do not drive, use machinery, or do any activity that requires clear vision until you are sure you can perform such activities safely.
Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.
Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.
Some products that may interact with this drug include: products applied to the eye (such as eye drops).
Overdose is unlikely with aflibercept as it is given by a health care professional. However, if overdose is suspected, contact a poison control center or emergency room immediately. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.
Your doctor will schedule periodic eye exams to monitor your progress and check for side effects.
For the best possible benefit, it is important to receive each scheduled dose of this medication as directed. If you miss a dose, contact your doctor to establish a new dosing schedule.
Not applicable. This medication is given in a hospital or doctor's office and will not be stored at home.
Information last revised August 2014. Copyright(c) 2014 First Databank, Inc.
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