If you are:
Possibly Safe: INSUFFICIENT HUMAN DATA AVAILABLE
Precaution: NO KNOWN INFANT ADVERSE OUTCOMES; MFR ADVISES CAUTION
Precaution: INSUFFICIENT HUMAN DATA; POTENTIAL FOR EXCRETION BASED ON DRUG PROPERTIES
An adult over 60:
management or monitoring precaution: Renal-Increased risk for drug induced metabolic acidosis with increasing age and declining renal function. Metformin is contraindicated in patients with an eGFR below 30 mL/min. Cardiovascular-Heart failure patients may have a higher risk for metabolic acidosis.
management or monitoring precaution: Renal-Adjust dosage for moderate to severe renal impairment. Monitor renal function.
Giving Janumet XR to a child under 12:
management or monitoring precaution: Safety and efficacy in pediatrics not established.
management or monitoring precaution: Rare reports of cholestatic and hepatocellular injury. No pediatric safety/efficacy of extended release dose form.