Skip to content
My WebMD Sign In, Sign Up
Limbitrol DS

Interactions

Tricyclic Compounds/Terbinafine

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Terbinafine may slow down how quickly your liver processes your tricyclic medicine.

What might happen:

The amount of tricyclic medicine in your blood may increase and cause an increase in side effects.

What you should do about this interaction:

Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. If you experience weakness, tiredness, dizziness, irregular heartbeat, confusion, anxiety, nervousness, difficulty sleeping, or problems urinating, contact your doctor. It may be necessary to adjust the dose of your medicine. Let your doctor know when you stop taking terbinafine. It may be necessary to increase the dose of your tricyclic medicine a few weeks after you stop taking terbinafine.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

References:

1.Lamisil (terbinafine hydrochloride) tablet US prescribing information. Novartis Pharmaceuticals Corporation June, 2013.

2.Madani S, Barilla D, Cramer J, Wang Y, Paul C. Effect of terbinafine on the pharmacokinetics and pharmacodynamics of desipramine in healthy volunteers identified as cytochrome P450 2D6 (CYP2D6) extensive metabolizers. J Clin Pharmacol 2002 Nov;42(11):1211-8.

3.O'Reardon JP, Hetznecker JM, Rynn MA, Baldassano CF, Szuba MP. Desipramine toxicity with terbinafine. Am J Psychiatry 2002 Mar;159(3):492.

4.Teitelbaum ML, Pearson VE. Imipramine toxicity and terbinafine. Am J Psychiatry 2001 Dec;158(12):2086.

5.Van Der Kuy PH, Van Den Heuvel HA, Kempen RW, Vanmolkot LM. Pharmacokinetic interaction between nortriptyline and terbinafine. Ann Pharmacother 2002 Nov;36(11):1712-4.

6.van der Kuy PH, Hooymans PM. Nortriptyline intoxication induced by terbinafine. BMJ 1998 Feb 7;316(7129):441.

7.Schmutz JL, Barbaud A, Trechot P. Overdose of nortriptyline during treatment with terbinafine (1st reported case). Ann Dermatol Venereol 1999 Aug-Sep;126(8-9):647.

8.Lamisil (terbinafine) UK summary of product characteristics. Novartis Pharmaceutical UK Ltd June, 2008.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

More about Drugs and Medications

Newsletters

Subscribe to free WebMD newsletters.

  • WebMD Daily

    WebMD Daily

    Subscribe to the WebMD Daily, and you'll get today's top health news and trending topics, and the latest and best information from WebMD.

  • Men's Health

    Men's Health

    Subscribe to the Men's Health newsletter for the latest on disease prevention, fitness, sex, nutrition, and more from WebMD.

  • Women's Health

    Women's Health

    Subscribe to the Women's Health newsletter for the latest on disease prevention, fitness, sex, diet, anti-aging, and more from WebMD.

By clicking Submit, I agree to the WebMD Terms & Conditions & Privacy Policy

URAC: Accredited Health Web Site HONcode Seal AdChoices