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Lotrel

Interactions

Ace Inhibitors; ARBs/Loop Diuretics

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

The cause of the interaction is not known. Loop diuretics may increase the effects of the ACE inhibitor and the angiotensin II receptor antagonists.

What might happen:

Your blood pressure may decrease, causing weakness, dizziness, or fatigue. This is more likely to occur during the first few days after the ACE inhibitor or angiotensin II receptor antagonist is added to your diuretic.

What you should do about this interaction:

If you experience weakness, fatigue, or dizziness contact your doctor. The dose of your medicines may need to be adjusted.Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this drug interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

References:

1.Ferguson RK, Vlasses PH, Koplin JR, Shirinian A, Burke JF Jr, Alexander JC. Captopril in severe treatment-resistant hypertension. Am Heart J 1980 May;99(5):579-85.

2.Case DB, Atlas SA, Laragh JH, Sealey JE, Sullivan PA, McKinstry DN. Clinical experience with blockade of the renin-angiotensin-aldosterone system by an oral converting-enzyme inhibitor (SQ 14,225, captopril) in hypertensive patients. Prog Cardiovasc Dis 1978 Nov-Dec;21(3):195-206.

3.Koffer H, Vlasses PH, Ferguson RK, Weis M, Adler AG. Captopril in diuretic-treated hypertensive patients. JAMA 1980 Dec 5;244(22):2532-5.

4.Heel RC, Brogden RN, Speight TM, Avery GS. Captopril: a preliminary review of its pharmacological properties and therapeutic efficacy. Drugs 1980 Dec;20(6):409-52.

5.Funck-Brentano C, Chatellier G, Alexandre JM. Reversible renal failure after combined treatment with enalapril and frusemide in a patient with congestive heart failure. Br Heart J 1986 Jun;55(6):596-8.

6.Anonymous. Reversible renal failure after combined treatment with enalapril and frusemide in a patient with congestive heart failure. Br Heart J 1986 Nov;56(5):489-90.

7.Van Hecken AM, Verbesselt R, Buntinx A, Cirillo VJ, De Schepper PJ. Absence of a pharmacokinetic interaction between enalapril and frusemide. Br J Clin Pharmacol 1987 Jan;23(1):84-7.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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