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Interactions

Dantrolene/Calcium Channel Blockers

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Both medicines affect how your heart uses calcium.

What might happen:

When used to treat or prevent a condition known as malignant hyperthermia, the combination can cause serious and potentially life-threatening affects on the heart.

What you should do about this interaction:

Malignant hyperthermia can be caused by anesthesia and/or surgery. Before any surgery, be sure to let your healthcare professionals (e.g. doctor or pharmacist) know of all the medicines you take.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

References:

1.Goodman-Gilman A. In Gilman AG, Rall TW, Nies AS, Taylor P, editors: Goodman and Gilman's The Phamacological Basis of Therapeutics. 8th edition. Elmsford, New York: Pergamon Press, Inc. 1990.

2.Dantrium (dantrolene sodium) US prescribing information. JHP Pharmaceuticals, LLC. July, 2012.

3.Sennesael J, Lamote J, Violet I, Tasse S, Verbeelen D. Comparison of perindopril and amlodipine in cyclosporine-treated renal allograft recipients. Hypertension 1995 Sep;26(3):436-44.

4.Saltzman LS, Kates RA, Corke BC, Norfleet EA, Heath KR. Hyperkalemia and cardiovascular collapse after verapamil and dantrolene administration in swine. Anesth Analg 1984 May;63(5):473-8.

5.San Juan AC Jr, Wong KC, Port JD. Hyperkalemia after dantrolene and verapamil-dantrolene administration in dogs. Anesth Analg 1988 Aug; 67(8):759-62.

6.Saltzman LS, Kates RA, Norfleet EA, Corke BC, Heath KR. Hemodynamic interactions of diltiazem-dantrolene and nifedipine-dantrolene. Anesthesiology 1984.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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