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    alogliptin-pioglitazone

    precautions

    What should I know regarding pregnancy, nursing and administering alogliptin-pioglitazone to children or the elderly?

    If you are:

    Pregnant:

    FDB Only When Necessary: INSUFF HUMAN DATA; POORLY CONTROLLED DIABETES MAY INCREASE MATERNAL/FETAL RISK

    FDB Only When Necessary: INSUFFICIENT HUMAN DATA AVAILABLE; NO DEVELOPMENTAL TOXICITY SEEN IN ANIMALS

    Nursing:

    Precaution: INSUFFICIENT DATA AVAILABLE; ALTERNATIVE AGENTS MAY BE PREFERRED

    Precaution: INSUFFICIENT HUMAN DATA AVAILABLE; EXCRETED IN RATS

    An adult over 60:

    management or monitoring precaution: Cardiovascular-Box warning states the drug may cause or exacerbate CHF. Contraindicated in patients with NYHA Class III or IV heart failure. Monitor for weight gain, peripheral edema and new onset dyspnea. Hepatic-Monitor for elevations of serum transaminases. Musculoskeletal-Consider increased fracture risk.

    Giving alogliptin-pioglitazone to a child under 12:

    Severe Precaution: Possible risks include fracture, fluid retention and heart failure, bladder tumor. Not recommended.

    management or monitoring precaution: Safety and efficacy not established.

    Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

    CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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