Skip to content
My WebMD Sign In, Sign Up
Drugs & Medications

alogliptin-pioglitazone

COMMON BRAND NAME(S): Oseni

GENERIC NAME(S): ALOGLIPTIN BENZOATE/PIOGLITAZONE HCL

WARNINGS:

This medication may infrequently cause or worsen a certain heart problem (congestive heart failure). Tell your doctor right away if you notice any symptoms of heart failure, including swelling of the hands/feet, unusual/sudden weight gain, trouble breathing, or unusual tiredness.

This medication is not recommended in patients with certain types of heart failure. Before using this medication, tell your doctor if you have heart failure.

Who should not take alogliptin-pioglitazone?
See More

Uses

This combination medication is used with a proper diet and exercise program and possibly with other medications to control high blood sugar. It is used by people with type 2 diabetes. Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems. Proper control of diabetes may also lessen your risk of a heart attack or stroke.

This product contains 2 medications: alogliptin and pioglitazone. Alogliptin works by increasing levels of natural substances called incretins. Incretins help to control blood sugar by increasing insulin release, especially after a meal. They also decrease the amount of sugar your liver makes. Pioglitazone works by helping to restore your body's proper response to insulin.

How to use alogliptin-pioglitazone

Read the Medication Guide provided by your pharmacist before you start using alogliptin/pioglitazone and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth as directed by your doctor, usually once daily with or without food. The manufacturer directs not to split/crush the tablet before taking it. However, many similar drugs (immediate-release tablets) can be split/crushed. Follow your doctor's directions on how to take this medication.

The dosage is based on your medical condition and response to treatment. Take this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day. Carefully follow your diabetes management plan, including medications, diet, and exercise.

Check your blood sugar regularly as directed by your doctor. Keep track of the results, and share them with your doctor. Tell your doctor if your blood sugar measurements are often too high or too low. Your doctor may need to adjust your diabetes medication, exercise program, or diet.

Side Effects

See also Warning section.

Sore throat, muscle pain, or weight gain may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: new/worsening vision problems (such as blurred vision), bone fracture, reddish-colored urine, frequent/painful urination.

Stop taking this medication and tell your doctor right away if any of these very serious side effects occur: signs of pancreatitis (such as persistent nausea/vomiting, loss of appetite, severe stomach/abdominal/back pain), dark urine, yellowing eyes/skin.

Although this medication by itself usually does not cause low blood sugar (hypoglycemia), low blood sugar may occur if this drug is prescribed with other anti-diabetic medications. Talk with your doctor or pharmacist about all your diabetic medication(s).

Symptoms of low blood sugar include sudden sweating, shaking, fast heartbeat, hunger, blurred vision, dizziness, or tingling hands/feet. It is a good habit to carry glucose tablets or gel to treat low blood sugar. If you don't have these reliable forms of glucose, rapidly raise your blood sugar by eating a quick source of sugar such as table sugar, honey, or candy, or drink fruit juice or non-diet soda. Tell your doctor about the reaction immediately. Low blood sugar is more likely if you drink large amounts of alcohol, do unusually heavy exercise, or do not consume enough calories from food. To help prevent low blood sugar, eat meals on a regular schedule, and do not skip meals. Talk with your doctor or pharmacist about what to do if you miss a meal.

Symptoms of high blood sugar (hyperglycemia) include thirst, increased urination, confusion, drowsiness, flushing, rapid breathing, or fruity breath odor. If these symptoms occur, tell your doctor right away. Your doctor may need to adjust your diabetes medication(s).

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking this medication, tell your doctor or pharmacist if you are allergic to alogliptin or pioglitazone; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: bladder cancer, heart problems (such as congestive heart failure, chest pain), kidney disease, liver problems, fluid in your lungs, a certain eye problem (macular edema), disease of the pancreas (pancreatitis), stones in your gallbladder (gallstones), swelling (edema).

You may experience blurred vision, dizziness, or drowsiness due to extremely low or high blood sugar levels. Do not drive, use machinery, or do any activity that requires alertness or clear vision until you are sure you can perform such activities safely.

Limit alcohol while taking this medication because it can increase the risk of developing low blood sugar.

It may be harder to control your blood sugar when your body is stressed (such as due to fever, infection, injury, or surgery). Consult your doctor because this may require a change in your treatment plan, medications, or blood sugar testing.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

This medication may increase the risk of bone fracture (usually in the forearm, wrist, hand, or foot), especially in women. See also Notes section.

This medication can cause changes in a woman's menstrual cycle (promote ovulation) and increase the chance of pregnancy. Consult your doctor or pharmacist about using reliable birth control while taking this medication.

During pregnancy this medication should be used only when clearly needed. Pregnancy may cause or worsen diabetes. Discuss a plan with your doctor for managing your blood sugar while pregnant. Your doctor may change your diabetes treatment during your pregnancy (such as diet, exercise, and medications including insulin).

It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Other medications can affect the removal of this medication from your body, which may affect how alogliptin/pioglitazone works. Examples include gemfibrozil, rifamycins (such as rifampin/rifabutin), among others.

Beta-blocker medications (such as metoprolol, propranolol, glaucoma eye drops such as timolol) may prevent the fast/pounding heartbeat you would usually feel when your blood sugar level falls too low (hypoglycemia). Other symptoms of low blood sugar, such as dizziness, hunger, or sweating, are unaffected by these drugs.

Many drugs can affect your blood sugar levels, making it more difficult to control your blood sugar. Before you start, stop, or change any medication, talk with your doctor or pharmacist about how the medication may affect your blood sugar. Check your blood sugar levels regularly as directed by your doctor. Tell your doctor about the results and of any symptoms of high or low blood sugar. (See also Side Effects section.) Your doctor may need to adjust your anti-diabetic medication, exercise program, or diet.

Overdose

If overdose is suspected, contact a poison control center or emergency room immediately. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Notes

Do not share this medication with others.

Attend a diabetes education program to learn more about diabetes and the important parts of its treatment, including medications, diet, exercise, and having regular eye/foot/medical exams.

Learn the symptoms of high and low blood sugar and how to treat low blood sugar. Check your blood sugar levels regularly as directed.

Keep all regular medical and laboratory appointments. Laboratory and/or medical tests (such as kidney/liver function, blood glucose, hemoglobin A1c, complete blood counts, eye exams) should be performed before you start treatment and periodically to monitor your progress or check for side effects.

Lifestyle changes that help promote healthy bones include increasing weight-bearing exercise, eating well-balanced meals containing adequate calcium and vitamin D, stopping smoking, and limiting alcohol. Consult your doctor about calcium/vitamin D supplements and to discuss lifestyle changes that might benefit you.

Missed Dose

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Storage

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

MEDICAL ALERT: Your condition can cause complications in a medical emergency. For information about enrolling in MedicAlert, call 1-888-633-4298 (US) or 1-800-668-1507 (Canada).

Information last revised May 2014. Copyright(c) 2014 First Databank, Inc.

Images

OSENI 25-45 MG TABLET
OSENI 25-45 MG TABLET
View Larger Picture
color
No data.
shape
No data.
imprint
No data.
OSENI 25-15 MG TABLET
OSENI 25-15 MG TABLET
View Larger Picture
color
No data.
shape
No data.
imprint
No data.
OSENI 12.5-45 MG TABLET
OSENI 12.5-45 MG TABLET
View Larger Picture
color
No data.
shape
No data.
imprint
No data.
OSENI 12.5-15 MG TABLET
OSENI 12.5-15 MG TABLET
View Larger Picture
color
No data.
shape
No data.
imprint
No data.
OSENI 12.5-30 MG TABLET
OSENI 12.5-30 MG TABLET
View Larger Picture
color
No data.
shape
No data.
imprint
No data.
OSENI 25-30 MG TABLET
OSENI 25-30 MG TABLET
View Larger Picture
color
No data.
shape
No data.
imprint
No data.
OSENI 25-45 MG TABLET
OSENI 25-45 MG TABLET

Identification

color
No data.
shape
No data.
imprint
No data.
This medicine is a red, round, film-coated tablet imprinted with "A/P 25 / 45".
OSENI 25-15 MG TABLET
OSENI 25-15 MG TABLET

Identification

color
No data.
shape
No data.
imprint
No data.
This medicine is a yellow, round, film-coated tablet imprinted with "A/P 25 / 15".
OSENI 12.5-45 MG TABLET
OSENI 12.5-45 MG TABLET

Identification

color
No data.
shape
No data.
imprint
No data.
This medicine is a pale red, round, film-coated tablet imprinted with "A/P 12.5 / 45".
OSENI 12.5-15 MG TABLET
OSENI 12.5-15 MG TABLET

Identification

color
No data.
shape
No data.
imprint
No data.
This medicine is a pale yellow, round, film-coated tablet imprinted with "A/P 12.5 / 15".
OSENI 12.5-30 MG TABLET
OSENI 12.5-30 MG TABLET

Identification

color
No data.
shape
No data.
imprint
No data.
This medicine is a pale peach, round, film-coated tablet imprinted with "A/P 12.5 / 30".
OSENI 25-30 MG TABLET
OSENI 25-30 MG TABLET

Identification

color
No data.
shape
No data.
imprint
No data.
This medicine is a peach, round, film-coated tablet imprinted with "A/P 25 / 30".

Add to Cabinet

Add Adderall to my medicine cabinet.

Did you know?

With WebMD's Medicine Cabinet, you can check interactions with drugs.

Go to medicine cabinet

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

More about Drugs and Medications

Newsletters

Subscribe to free WebMD newsletters.

  • WebMD Daily

    WebMD Daily

    Subscribe to the WebMD Daily, and you'll get today's top health news and trending topics, and the latest and best information from WebMD.

  • Men's Health

    Men's Health

    Subscribe to the Men's Health newsletter for the latest on disease prevention, fitness, sex, nutrition, and more from WebMD.

  • Women's Health

    Women's Health

    Subscribe to the Women's Health newsletter for the latest on disease prevention, fitness, sex, diet, anti-aging, and more from WebMD.

By clicking Submit, I agree to the WebMD Terms & Conditions & Privacy Policy

URAC: Accredited Health Web Site TRUSTe online privacy certification HONcode Seal AdChoices