Skip to content
My WebMD Sign In, Sign Up
Arava

Interactions

Leflunomide; Teriflunomide/Methotrexate

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

When these two medicines are taken together, harmful effects on your liver, blood, and/or lungs may result.

What might happen:

You may experience an increased chance for toxic effects to your liver. Nausea, stomach pain, yellowing of the skin or eyes, dark urine, fever, or fatigue may be signs of liver problems. The number of cells in your blood may decrease. You may become tired easily, may bleed or bruise more easily, and may be more likely to get an infection. There is a small risk that you could develop an inflammation in your lungs.

What you should do about this interaction:

Be sure to get all of the blood tests that your doctor orders. If you have any symptoms of liver or blood problems, contact your doctor. Contact your doctor right away if you have any new or worsening of shortness of breath and/or cough, with or without a fever. It may be necessary to change one or both of your medicines.Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this drug interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

References:

1.Arava (leflunomide) US prescribing information. Aventis Pharmaceuticals, Inc. November, 2012.

2.Dear Healthcare Professional: Arava (leflunomide) and interstitial lung disease. Aventis Pharma, Inc. June 21, 2004.

3.Aubagio (teriflunomide) US prescribing information. Genzyme Corporation September, 2012.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

More about Drugs and Medications

Newsletters

Subscribe to free WebMD newsletters.

  • WebMD Daily

    WebMD Daily

    Subscribe to the WebMD Daily, and you'll get today's top health news and trending topics, and the latest and best information from WebMD.

  • Men's Health

    Men's Health

    Subscribe to the Men's Health newsletter for the latest on disease prevention, fitness, sex, nutrition, and more from WebMD.

  • Women's Health

    Women's Health

    Subscribe to the Women's Health newsletter for the latest on disease prevention, fitness, sex, diet, anti-aging, and more from WebMD.

By clicking Submit, I agree to the WebMD Terms & Conditions & Privacy Policy

URAC: Accredited Health Web Site TRUSTe online privacy certification HONcode Seal AdChoices