Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
When indinavir is taken with delavirdine, your body may process indinavir more slowly. When indinavir is taken with efavirenz, your body may process indinavir more quickly.
What might happen:
When indinavir is taken with delaviridine, levels of indinavir may increase. This may cause pain in your side, blood in your urine, nausea, vomiting, or diarrhea.When indinavir is taken with efavirenz, the beneficial effects of indinavir may decrease.
What you should do about this interaction:
Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this drug interaction and may be monitoring you for it. If you are taking indinavir with delavirdine and you notice any pain in your side, blood in your urine, nausea, vomiting, or diarrhea, contact your healthcare professional. If your doctor prescribes these medicines together, it may be necessary to adjust your dose of indinavir. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Rescriptor (delavirdine mesylate) US prescribing information. Pharmacia & Upjohn Company August, 2012.
2.Crixivan (indinavir sulfate) US prescribing information. Merck & Co., Inc. July, 2014.
3.Sustiva (efavirenz) US prescribing information. Bristol-Myers Squibb Company May 23, 2014.
4.Atripla (efavirenz/emtricitabine/tenofovir disoproxil fumarate) US prescribing information. Gilead Sciences, Inc. October, 2013.