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efavirenz

Interactions

Indinavir/Delavirdine; Efavirenz

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

When indinavir is taken with delavirdine, your body may process indinavir more slowly. When indinavir is taken with efavirenz, your body may process indinavir more quickly.

What might happen:

When indinavir is taken with delaviridine, levels of indinavir may increase. This may cause pain in your side, blood in your urine, nausea, vomiting, or diarrhea.When indinavir is taken with efavirenz, the beneficial effects of indinavir may decrease.

What you should do about this interaction:

Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this drug interaction and may be monitoring you for it. If you are taking indinavir with delavirdine and you notice any pain in your side, blood in your urine, nausea, vomiting, or diarrhea, contact your healthcare professional. If your doctor prescribes these medicines together, it may be necessary to adjust your dose of indinavir. Do not start, stop, or change the dosage of any medicine before checking with them first.

References:

1.Rescriptor (delavirdine mesylate) US prescribing information. Pharmacia & Upjohn Company August, 2012.

2.Crixivan (indinavir sulfate) US prescribing information. Merck & Co., Inc. February, 2011.

3.Sustiva (efavirenz) US prescribing information. Bristol-Myers Squibb Company August, 2012.

4.Atripla (efavirenz/emtricitabine/tenofovir disoproxil fumarate) US prescribing information. Gilead Sciences, Inc. October, 2013.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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