Severe. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Both of these medicines can harm your kidneys.
What might happen:
Taking these medicines together increases your risk of developing problems with your kidneys.
What you should do about this interaction:
If you are taking these medicines together, let your healthcare professional (e.g. doctor or pharmacist) know. If you doctor decides that this is the best therapy for you, your doctor will closely monitor the amounts of tacrolimus and cyclosporine in your blood, as well as your kidney function. Be sure to keep all laboratory appointments.If your doctor is switching you from tacrolimus to cyclosporine or from cyclosporine to tacrolimus, your doctor may want you to wait at least 24 hours after your last dose of the first medicine before beginning the second medicine. If the reason you are switching medicines is because you are already having problems with your kidneys, your doctor may want you to wait longer between the medicines.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Prograf (tacrolimus) US prescribing information. Fujisawa Healthcare, Inc. September, 2013.
2.Neoral (cyclosporine) US prescribing information. Novartis Pharmaceuticals Corporation March, 2015.
3.Sandimmune (cyclosporine) US prescribing information. Novartis Pharmaceuticals Corporation March, 2015.
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