Severe. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
The cause of the interaction is not known. Alitretinoin or bexarotene may increase the effects of diethyltoluamide (DEET).
What might happen:
When alitretinoin or bexarotene are used with DEET, the toxic effects of DEET may increase.
What you should do about this interaction:
If you are using alitretinoin or bexarotene, avoid products that contain DEET. If you have questions about using these products together, contact your healthcare professionals (e.g. doctor or pharmacist). Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Panretin (alitretinoin) US prescribing information. Ligand Pharmaceuticals Incorporated November, 2013.
2.Targretin (bexarotene) Gel US prescribing information. Ligand Pharmaceuticals Incorporated January, 2001.