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Verelan PM

Interactions

Verapamil/Grapefruit Juice

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug, changing your diet or commencing any course of treatment.

Medical warning:

Important. Possible changes in your diet, medicine, or dosage should be discussed with your doctor or pharmacist.

How the interaction occurs:

When grapefruit or grapefruit juice is taken with verapamil, it may increase the amount of this medicine absorbed into your bloodstream.

What might happen:

Your blood levels of verapamil may increase. Increased blood levels may cause a lower-than-desired blood pressure or an undesirable change in heart rate.

What you should do about this interaction:

While you are taking this medicine, you may want to consider avoiding eating grapefruit or drinking grapefruit juice. You may choose an alternative citrus beverage (such as orange juice). In the event that you are instructed by a healthcare professional (e.g., doctor, pharmacist, or dietitian) to eat grapefruit or drink grapefruit juice, you should immediately discuss with your doctor the effects of grapefruit on the blood levels of this medicine.Tell your doctor immediately if symptoms of low blood pressure (such as rapid heartbeat or dizziness) occur. Also report an irregular or unusually slow heartbeat. Contact your healthcare professional for more information.Your healthcare professional may be aware of this interaction and may be monitoring you for it. Do not start, stop, or change your medicine or diet before checking with them first.

References:

1.Ho PC, Ghose K, Saville D, Wanwimolruk S. Effect of grapefruit juice on pharmacokinetics and pharmacodynamics of verapamil enantiomers in healthy volunteers. Eur J Clin Pharmacol 2000 Dec;56(9-10):693-8.

2.Zaidenstein R, Dishi V, Gips M, Soback S, Cohen N, Weissgarten J, Blatt A, Golik A. The effect of grapefruit juice on the pharmacokinetics of orally administered verapamil. Eur J Clin Pharmacol 1998 Jun;54(4):337-40.

3.Fuhr U, Muller-Peltzer H, Kern R, Lopez-Rojas P, Junemann M, Harder S, Staib AH. Effects of grapefruit juice and smoking on verapamil concentrations in steady state. Eur J Clin Pharmacol 2002 Apr;58(1):45-53.

4.Covera-HS (verapamil hydrochloride) US prescribing information. G.D. Searle LLC November, 2011.

5.Grapefruit juice interactions with drugs. Med Lett Drugs Ther 1995 Aug 18; 37(955):73-4.

6.Bailey DG, Malcolm J, Arnold O, Spence JD. Grapefruit juice-drug interactions. Br J Clin Pharmacol 1998 Aug;46(2):101-10.

7.Pillai U, Muzaffar J, Sen S, Yancey A. Grapefruit juice and verapamil: a toxic cocktail. South Med J 2009 Mar;102(3):308-9.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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