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Norvir Soft Gelatin

Interactions

Vinblastine; Vincristine/Ritonavir

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Ritonavir may slow down how quickly your liver processes vinblastine and vincristine.

What might happen:

The amount of vinblastine or vincristine in your blood may increase and cause serious side effects.

What you should do about this interaction:

Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Let your doctor know right away if you develop any signs of an infection, such as fever, chills, or persistent sore throat; have severe nausea, vomiting, or diarrhea; muscle weakness; numbness or loss of feeling; abdominal pain; constipation; seizures; or swelling. Your doctor may need to change your HIV therapy or may need to stop it during your chemotherapy.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

References:

1.Norvir (ritonavir) US prescribing information. Abbott Laboratories November, 2012.

2.Kaletra (lopinavir/ritonavir tablets) US prescribing information. Abbott Laboratories January, 2013.

3.Makinson A, Martelli N, Peyriere H, Turriere C, Le Moing V, Reynes J. Profound neutropenia resulting from interaction between antiretroviral therapy and vinblastine in a patient with HIV-associated Hodgkin's disease. Eur J Haematol 2007 Apr;78(4):358-60.

4.Kotb R, Vincent I, Dulioust A, Peretti D, Taburet AM, Delfraissy JF, Goujard C. Life-threatening interaction between antiretroviral therapy and vinblastine in HIV-associated multicentric Castleman's disease. Eur J Haematol 2006 Mar;76(3):269-71.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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