Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
It is not know how this interaction occurs.
What might happen:
The amount of tacrolimus in your blood may decrease and it may not work as well. You may have a higher risk of developing kidney problems or diabetes and your body may have trouble healing wounds.If you take these medicines together after receiving a liver or lung transplant, your transplanted organ may be damaged.
What you should do about this interaction:
If your healthcare professionals (e.g. doctor or pharmacist) believe that this combination of medicines is the best therapy for you, they will closely monitor you while you are taking these medicines. Let your doctor know right away if you have any changes in your condition or if you develop a wound that does not heal properly or as soon as expected. Discuss any concerns you have with your healthcare professionals.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Torisel (temsirolimus) US prescribing information. Wyeth Pharmaceuticals, Inc. June, 2011.
2.Filler G, Womiloju T, Feber J, Lepage N, Christians U. Adding sirolimus to tacrolimus-based immunosuppression in pediatric renal transplant recipients reduces tacrolimus exposure. Am J Transplant 2005 Aug; 5(8):2005-10.
3.Dear Healthcare Provider letter on Rapamune (sirolimus). Wyeth Laboratories February, 2003.
4.Rapamune (sirolimus) US prescribing information. Wyeth Pharmaceuticals March, 2013.
5.Prograf (tacrolimus) US prescribing information. Fujisawa Healthcare, Inc. September, 2013.