Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
When these two medicines are taken together, your body may process valproic acid more slowly.
What might happen:
The blood levels of valproic acid may increase and cause toxic effects.
What you should do about this interaction:
If you develop confusion, dizziness, or other unusual effects, contact your doctor. The dose of your medicines may need adjusting.Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this drug interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Felbatrol (felbamate) US prescribing information. MedPoint Pharmaceuticals Inc. August 27, 2012.
2.Wagner ML, Graves NM, Leppik IE, Remmel RP, Ward DL, Shumaker RC. The effect of felbamate on valproate disposition. Epilepsia 1991;32(3):15.