Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Lopinavir, saquinavir or your hepatitis C medicine may speed up how quickly your liver processes darunavir.Darunavir may slow down how quickly your liver processes lopinavir.
What might happen:
The amount of darunavir in your blood may decrease and it may not work as well against your HIV infection.Darunavir may cause amount of lopinavir in your blood to increase and cause more side effects than normal.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Your doctor may want to check how well your darunavir is working. Let your doctor know if you have any side effects from your medicine. Your doctor may want to change your medicine.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Prezista (darunavir) US prescribing information. Tibotec Inc. May, 2015.
2.Viekira Pak (ombitasvir, paritaprevir, and ritonavir; dasabuvir) US prescribing information. AbbVie Inc. April, 2016.
3.FDA. CDER Application number: 2066190 Viekira Pak (ombitasvir, paritaprevir, ritonavir, dasabuvir) Clinical Pharmacology and Biopharmaceutics Review(s). URL: http://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/206619Orig1s000Clin PharmR.pdf December 19, 2014.