How the interaction occurs:
Zidovudine may decrease the transformation of stavudine to its active form.
What might happen:
The levels of the active form of stavudine in your blood may decrease and it may not be as effective.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Your medicine may need to be changed.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Hoggard P, Khoo S, Barry M, Back D. Intracellular metabolism of zidovudine and stavudine in combination. J Infect Dis 1996 Sep;174(3):671-2.
2.Havlir DV, Tierney C, Friedland GH, Pollard RB, Smeaton L, Sommadossi JP, Fox L, Kessler H, Fife KH, Richman DD. In vivo antagonism with zidovudine plus stavudine combination therapy. J Infect Dis 2000 Jul;182(1):321-5.
3.Retrovir (zidovudine) US prescribing information. GlaxoSmithKline November, 2011.
4.Zerit (stavudine) US prescribing information. Bristol-Myers Squibb Company November, 2011.