Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
The cause of the interaction is not known.
What might happen:
When these medicines are taken together, your blood levels of both sirolimus and cyclosporine may increase. This may cause problems with your kidneys.
What you should do about this interaction:
Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this interaction and may be monitoring you for it. Your doctor may want to check your blood levels of sirolimus and cyclosporine more often. Your doctor may also want you to take sirolimus four hours after you take your cyclosporine. However, do not change the times when you take your medicines or their doses, or start or stop taking them before checking with your healthcare professional first.
1.Torisel (temsirolimus) US prescribing information. Wyeth Pharmaceuticals, Inc. June, 2011.
2.Rapamune (sirolimus) US prescribing information. Wyeth Pharmaceuticals March, 2013.