This medication may cause or worsen some serious medical conditions, including psychiatric conditions (e.g., depression); immune disorders (autoimmune conditions such as rheumatoid arthritis or lupus); circulation problems (e.g., cardiovascular disease); or infections (bone marrow suppression). Seek immediate medical attention if you develop any serious symptoms or side effects (see Side Effects section). These conditions occur rarely, but some may be fatal.
This medicine is frequently combined with ribavirin. Ribavirin may cause harm to an unborn baby or death. Women must avoid pregnancy while they or their male partners are using ribavirin. Ribavirin may cause a blood disorder (hemolytic anemia), which can worsen heart disease. If you are using peginterferon alfa-2b with ribavirin to treat chronic hepatitis C, also carefully read the drug information for ribavirin.Who should not take Peginterferon Alfa-2B Kit?
This medication reduces the amount of hepatitis C virus in the body and helps the body's immune system fight the infection. It is not known if peginterferon can cure hepatitis C virus infections (permanently eliminate the virus from your body). It is also not known if this drug can prevent you from passing the virus to others. Practice "safe sex" (including the use of latex condoms) to lower the risk of passing the virus to others.
Read the Medication Guide and, if available, the Patient Information Leaflet provided by your pharmacist before you start using peginterferon alfa-2b and each time you get a refill. If you have any questions regarding the information, consult your doctor or pharmacist.
Inject this medication under the skin (subcutaneously) on your thigh or stomach as directed by your doctor, usually once weekly. Some brands may also be injected on the outer surface of your upper arm. Do not inject near the belly button or at the waistline. Use a different place each time you give yourself an injection. Do not shake this medication. Doing so may decrease the effectiveness of this medication. The dose should be given at about the same time on the same day each week. The dosage is based on your body weight, laboratory tests, medical condition and response to therapy.
If you are giving this medication to yourself at home, learn all preparation and usage instructions from your health care professional. Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid. Learn how to store and discard medical supplies safely.
Drink plenty of fluids while you are taking this medication, unless your doctor directs you otherwise. Additional administration guidelines may be available in the Medication Guide.
Flu-like symptoms (e.g., fever, chills, muscle aches, fatigue, headache, joint pain, nausea, stomach pain) may occur. If instructed to do so, taking pain/fever-reducing medications (e.g., acetaminophen, ibuprofen) or injecting this medication at bedtime may help reduce some of these symptoms. Dry mouth, increased sweating, loss of appetite, weight loss, trouble sleeping, diarrhea, dry skin, redness/swelling at the injection site, throat/sinus infections, or menstrual period problems may also occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.
Tooth and gum problems may sometimes occur during treatment. Having a dry mouth can worsen this side effect. Prevent dry mouth by drinking plenty of water or using a saliva substitute. Brush your teeth well at least twice a day and have regular dental exams. If you experience vomiting during treatment, rinse your mouth afterwards to lessen the chance of tooth and gum problems.
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Tell your doctor right away if you have any serious side effects, including: persistent sore throat or fever, easy or unusual bleeding/bruising, unusually severe fatigue, increased thirst/urination, unusually slow/fast/pounding heartbeat, severe stomach pain with nausea/vomiting, bloody diarrhea, numbness/tingling of arms/legs.
This drug may cause you to develop serious mental/mood changes that may get worse during treatment or after your last dose. Tell your doctor right away if you have symptoms such as confusion, depression, thoughts of suicide or hurting others, unusual irritability, or aggressive behavior. If this occurs, psychiatric therapy and monitoring is recommended during and after treatment with this medication.
A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
See also Warning section.
Before using peginterferon alfa-2b, tell your doctor or pharmacist if you are allergic to it; or to polyethylene glycol (PEG); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication tell your doctor or pharmacist your medical history, especially of: other liver disease (e.g., autoimmune hepatitis, hepatic decompensation), mental/mood disorders (e.g., depression), history of drug/alcohol abuse, sleep problems, low blood counts (e.g., red cells, white cells, or platelets), heart disease, thyroid problems, autoimmune disease (e.g., rheumatoid arthritis, lupus, psoriasis), eye problems, kidney disease, lung disease (e.g., COPD, asthma, pneumonia), cancer, inflammation of the bowels (e.g., colitis), pancreatitis, diabetes, other infections (HIV, hepatitis B), high blood triglyceride levels, history of organ transplant.
Use caution with sharp objects like safety razors or nail cutters and avoid activities such as contact sports to lower the chance of getting cut, bruised, or injured.
This drug may make you drowsy or dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely.
Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
Children may be more sensitive to the side effects of this drug, especially mental/mood changes (such as severe depression, thoughts/attempts of suicide). Peginterferon may also slow down a child's rate of growth. Normal weight gain and rate of growth usually return after treatment is completed but the final adult height may be lower than expected. Monitor your child's height and weight periodically during treatment.
Caution is advised when using this drug in the elderly because they may be more sensitive to its effects.
Peginterferon alfa-2b, when used in combination with ribavirin, must not be used during pregnancy by either the pregnant woman or her male partner. The combination may cause harm to an unborn baby. Two reliable forms of birth control (such as condoms, birth control pills) must be used whenever at least one sexual partner is using these medicines together, and for at least 6 months after stopping treatment. If you or your partner become pregnant, or if you think you or your partner may be pregnant, tell your doctor right away.
Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.
If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.
Laboratory and/or medical tests (such as blood counts, thyroid tests, virus levels, kidney/liver function, triglyceride levels, eye exams) should be performed before you start treatment, periodically to monitor your progress, or to check for side effects. Depending on your medical history, other tests (such as EKG) may be needed. Consult your doctor for more details.
If you miss a dose, take the missed dose as soon as possible during the same day or the next day, then continue on your regular dosing schedule. If several days go by after you miss a dose, contact your doctor or pharmacist to establish a new dosing schedule.
Store the pen in the refrigerator. Store the vials at room temperature away from light and moisture. Do not store in the bathroom. Each vial or pen can be used only once. Discard any unused portion. Keep all medications away from children and pets.
After mixing, if not used right away, the medication may be stored in the refrigerator for up to 24 hours. Do not freeze.
Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.Information last revised July 2016. Copyright(c) 2016 First Databank, Inc.
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