How the interaction occurs:
The pH of your GI tract needs to be acidic for your cancer medicine to dissolve and be absorbed. H2 blockers and proton pump inhibitors change the pH (acidity) your GI tract.
What might happen:
The amount of cancer medicine in your blood may decrease and it may not work as well.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Your doctor may instruct you to take antacids instead of your H2 blocker or proton pump inhibitor.If you need to use an antacid while on dasatinib or nilotinib, take the antacid at least 2 hours before or 2 hours after your dasatinib or nilotinib.If you need to use an antacid while on bosutinib, erlotinib, or pazopanib, separate the doses of the antacid and your cancer medicine by several hours.If you have questions about how to schedule your medicines, ask your pharmacist.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Bosulif (bosutinib) US prescribing information. Pfizer Inc. September, 2013.
2.Sprycel (dasatinib) US prescribing information. Bristol-Myers Squibb Company June, 2013.
3.Tarceva (erlotinib) US prescribing information. Genentech, Inc. April, 2012.
4.Tasigna (nilotinib) US prescribing information. Novartis Pharmaceuticals Corporation September, 2014.
5.Votrient (pazopanib) US prescribing information. GlaxoSmithKline June, 2014.
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7.Yin OQ, Gallagher N, Fischer D, Demirhan E, Zhou W, Golor G, Schran H. Effect of the Proton Pump Inhibitor Esomeprazole on the Oral Absorption and Pharmacokinetics of Nilotinib. J Clin Pharmacol 2010 May 24.
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