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Yasmin (28)


Hormonal Contraceptives/Carbamazepine; Rufinamide

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

When these two medicines are taken together, your body may process your birth control medicine more quickly.

What might happen:

The effects of your birth control medicine may decrease and cause breakthrough bleeding, spotting, or pregnancy.

What you should do about this interaction:

Talk to your healthcare professional (e.g. doctor or pharmacist) as soon as possible about using a different form of birth control. Contact your doctor if you experience breakthrough bleeding, spotting, or pregnancy.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.


1.Rapport DJ, Calabrese JR. Interactions between carbamazepine and birth control pills. Psychosomatics 1989 Fall;30(4):462-4.

2.Crawford P, Chadwick DJ, Martin C, Tjia J, Back DJ, Orme M. The interaction of phenytoin and carbamazepine with combined oral contraceptive steroids. Br J Clin Pharmacol 1990 Dec;30(6):892-6.

3.Nor-Q-D (norethindrone) US prescribing information. WatsonPharma March, 2005.

4.Doose DR, Wang SS, Padmanabhan M, Schwabe S, Jacobs D, Bialer M. Effect of topiramate or carbamazepine on the pharmacokinetics of an oral contraceptive containing norethindrone and ethinyl estradiol in healthy obese and nonobese female subjects. Epilepsia 2003 Apr;44(4):540-9.

5.Inovelon (rufinamide) UK summary of product characteristics. Eisai Limited January 16, 2007.

6.Banzel (rufinamide) US prescribing information. Eisai Inc. June, 2015.

7.Davis AR, Westhoff CL, Stanczyk FZ. Carbamazepine coadministration with an oral contraceptive: Effects on steroid pharmacokinetics, ovulation, and bleeding. Epilepsia 2011 Jan 4.

8.Wilbur K, Ensom MH. Pharmacokinetic drug interactions between oral contraceptives and second-generation anticonvulsants. Clin Pharmacokinet 2000 Apr;38(4):355-65.

9.Reddy DS. Clinical pharmacokinetic interactions between antiepileptic drugs and hormonal contraceptives. Expert Rev Clin Pharmacol 2010 Mar 1; 3(2):183-192.

10.Schindlbeck C, Janni W, Friese K. Failure of Implanon contraception in a patient taking carbamazepin for epilepsia. Arch Gynecol Obstet 2006 Jan; 273(4):255-6.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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