Severe. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
How this interaction occurs is not known.
What might happen:
When these medications are taken together, the levels of tenofovir in your blood may increase.This is more likely to occur if you have some existing kidney problems or taking other drugs removed by your kidneys. You may have more side effects from your tenofovir, such as nausea, vomiting, or diarrhea.
What you should do about this interaction:
Make sure your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Viread (tenofovir disoproxil fumarate) UK summary of product characteristics. Gilead Sciences, Ltd June 4, 2008.
2.Viread (tenofovir disoproxil fumarate) US prescribing information. Gilead Sciences, Inc. October, 2013.
3.Hepsera (adefovir dipivoxil) US prescribing information. Gilead Sciences, Inc. November, 2012.
4.Viread (tenofovir disoproxil fumarate) Canadian product information. Gilead Sciences, Inc. January 11, 2008.