How the interaction occurs:
When these two medicines are taken together, your body may not absorb digoxin properly.
What might happen:
Your blood levels of digoxin may decrease. This may decrease the beneficial effects of your digoxin.
What you should do about this interaction:
If you experience shortness of breath or a fast heartbeat, contact your doctor. It may be necessary to change the time you take each medicine or change you to a different medicine.Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Giesing DH, Lanman RC, Dimmitt DC, Runser DJ. Lack of effect of sucralfate on digoxin pharmacokinetics. Gastroenterology 1983 May;84(5 Part 2):1165.
2.Rey AM, Gums JG. Altered absorption of digoxin, sustained-release quinidine, and warfarin with sucralfate administration. DICP 1991 Jul-Aug; 25(7-8):745-6.
3.Brown DD, Juhl RP. Decreased bioavailability of digoxin due to antacids and kaolin-pectin. N Engl J Med 1976 Nov 4;295(19):1034-7.
4.McElnay JC, Harron DW, D'Arcy PF, Eagle MR. Interaction of digoxin with antacid constituents. Br Med J 1978 Jun 10;1(6126):1554.
5.Allen MD, Greenblatt DJ, Harmatz JS, Smith TW. Effect of magnesium--aluminum hydroxide and kaolin--pectin on absorption of digoxin from tablets and capsules. J Clin Pharmacol 1981 Jan;21(1):26-30.
6.Albert KS, Ayres JW, DiSanto AR, Weidler DJ, Sakmar E, Hallmark MR, Stoll RG, DeSante KA, Wagner JG. Influence of kaolin--pectin suspension on digoxin bioavailability. J Pharm Sci 1978 Nov;67(11):1582-6.
7.Albert KS, Elliot WJ, Abbott RD, Gilbertson TJ, Data JL. Influence of kaolin-pectin suspension on steady-state plasma digoxin levels. J Clin Pharmacol 1981 Oct;21(10):449-55.
8.Lanoxin (digoxin) Tablets US prescribing information. GlaxoSmithKline August, 2012.