Skip to content
My WebMD Sign In, Sign Up
niacin-lovastatin

Interactions

Lovastatin (<= 20 mg)/Danazol

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Danazol may slow down how quickly your liver processes your cholesterol medicine.

What might happen:

The amount of cholesterol medicine in your blood may increase and damage your muscles.

What you should do about this interaction:

Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Your doctor may want to lower your dose of your cholesterol medicine.Tell your doctor right away if you experience muscle pain, tenderness, or weakness; unexplained tiredness; or discolored urine.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

References:

1.Mevacor (lovastatin) US prescribing information. Merck & Co., Inc. February, 2014.

2.Hsieh CY, Chen CH. Rhabdomyolysis and pancreatitis associated with coadministration of danazol 600 mg/d and lovastatin 40 mg/d. Clin Ther 2008 Jul;30(7):1330-5.

3.Khanna S, Mundell WC. Rhadbomyolysis associated with co-administration of danazol and lovastatin. Br J Clin Pharmacol 2011 Jul;72(1):166-7.

4.Dallaire M, Chamberland M. Severe rhabdomyolysis in a patient receiving lovastatin, danazol, and doxycycline. CMAJ 1994 Jun 15;150(12):1991-4.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

More about Drugs and Medications

URAC: Accredited Health Web Site HONcode Seal AdChoices