Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Methadone may decrease how much didanosine and stavudine your body absorbs. Methadone may slow down how quickly your liver processes zidovudine.
What might happen:
The amount of didanosine and stavudine in your blood may decrease and they may not work as well against your HIV-infection.The amount of zidovudine in your blood may increase and cause more side effects than normal.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Your doctor may want to change the dose of your HIV-medicine. If you are taking didanosine and/or stavudine, your doctor may want to run some tests to make sure your medicines are working. If you are taking zidovudine, let your doctor know if you have any skin rashes, fever, sore throat, increased tiredness, weakness, unusual bleed or bruising, stomach pains, problems breathing, a change in urine color to brown, or changes in skin or eye color to yellow.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
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