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metoprolol tartrate-hydrochlorothiazide

Interactions

Beta-Blockers/Thioamines

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

When these two medicines are taken together, your body may not process beta-blockers properly.

What might happen:

You may experience an increase in the effects of your beta-blocker.

What you should do about this interaction:

If you experience a low heart rate, fatigue, weakness, or dizziness, contact your healthcare professional (e.g. doctor or pharmacist). It may be necessary to adjust the dose of your beta-blocker.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

References:

1.Bell JM, Russell CJ, Nelson JK, Kelly JG, McDevitt DG. Studies of the effect of thyroid dysfunction on the elimination of beta- adrenoreceptor blocking drugs. Br J Clin Pharmacol 1977 Feb;4(1):79-82.

2.Feely J, Stevenson IH, Crooks J. Increased clearance of propranolol in thyrotoxicosis. Ann Intern Med 1981 Apr;94(4 pt 1):472-4.

3.Feely J, Crooks J, Stevenson IH. Plasma propranolol steady state concentrations in thyroid disorders. Eur J Clin Pharmacol 1981; 19(5):329-33.

4.Feely J, Crooks J, Stevenson IH. The influence of age, smoking and hyperthyroidism on plasma propranolol steady state concentration. Br J Clin Pharmacol 1981 Jul;12(1):73-8.

5.Wells PG, Feely J, Nadeau J, Wilkinson GR, Wood AJJ. Propranolol disposition in thyrotoxicosis. Clin Res 1981;29(2):279A.

6.Aro A, Anttila M, Korhonen T, Sundquist H. Pharmacokinetics of propranolol and sotalol in hyperthyroidism. Eur J Clin Pharmacol 1982;21(5):373-7.

7.Hallengren B, Nilsson OR, Karlberg BE, Melander A, Tegler L, Wahlin-Boll E. Influence of hyperthyroidism on the kinetics of methimazole, propranolol, metoprolol and atenolol. Eur J Clin Pharmacol 1982; 21(5):379-84.

8.Wells PG, Feely J, Wilkinson GR, Wood AJ. Effect of thyrotoxicosis on liver blood flow and propranolol disposition after long-term dosing. Clin Pharmacol Ther 1983 May;33(5):603-8.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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