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    Promethazine VC-Codeine

    precautions

    What should I know regarding pregnancy, nursing and administering Promethazine VC-Codeine to children or the elderly?

    If you are:

    Pregnant:

    Only When Necessary: CAUTION WITH USE; RISK OF PLATELET AGGREGATION IN NEWBORN

    Only When Necessary: NEONATAL WITHDRAWAL/RESP.DEPRESS. W/CHRONIC OR HIGH DOSE; SMALL TERATOGENIC RISK

    Only When Necessary: EVIDENCE FOR MALFORMATIONS; CAN REDUCE UTERINE BLOOD FLOW CAUSING FETAL HYPOXIA

    Nursing:

    Precaution: LIMITED AMOUNT MAY BE EXCRETED DUE TO LOW MW; MONITOR INFANT FOR RESP DEPRESS

    Precaution: CNS/RESPIRATORY DEPRESSION,APNEA POSSIBLE;CAUTION W/ FAST CYP2D6 METABOLIZER

    Precaution: ORAL BIOAVAILABILITY LOW; INFANT EXPOSURE MAY BE MINIMAL

    An adult over 60:

    Precaution: (BEERS)(SOM) ANTICHOLINERGIC/HYPOTENSION/SEDATION;USEFUL FOR NAUSEA

    Precaution: (SOM)(BEERS) MORE SENSITIVE TO CV & CNS EFX; URINARY RET.,INSOMNIA.

    Precaution: (BEERS)RISKS:HYPOTENSION/RESP.DEPRESS/URINARY RET./CONFUSION/CONSTIP

    Giving Promethazine VC-Codeine to a child under 12:

    Absolute Contraindication: RISK OF CNS EXCITATION. DO NOT USE AGE <6 YEARS WITHOUT CLINICIAN CONSULT.

    Absolute Contraindication: POTENTIAL FOR FATAL RESPIRATORY DEPRESSION AGE < 2 YEARS. AVOID USE.

    Relative Contraindication: CAUTION:USE THE LOWEST EFFECTIVE DOSE; RISK OF RESPIRATORY DEPRESSION

    Relative Contraindication: CONTRAINDICATED ADENOID/TONSILLECTOMY. RISK W/RAPID 2D6;FATAL RESP DEPRES

    Absolute Contraindication: RISK OF FATAL RESP DEPRES W/RAPID 2D6 METABOLISM. CONTRAINDICATED AGE < 6 YRS

    Relative Contraindication: RISK W/RAPID 2D6;FATAL RESP DEPRES. CONTRAINDICATED ADENOID/TONSILLECTOMY.

    Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

    CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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