Severe. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Tretinoin and other medicines such as fluoroquinolones, phenothiazines, sulfonamides, and thiazides increase your sensitivity to sunlight.
What might happen:
Using tretinoin-mequinol with fluoroquinolones, phenothiazines, sulfonamides, or thiazides can increase your skin's sensitivity to sunlight. You may burn more quickly, your sunburn may be more severe than normal, and you may develop tingling in the skin.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know right away that you are taking these medicines together.Avoid prolonged sun exposure, tanning booths, and sunlamps. Use a sunscreen and wear protective clothing when outdoors.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.Reference:1.Solage (tretinoin-mequinol) US prescribing information. Barrier Therapeutics, Inc. April, 2007.