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Triamterene; Amiloride/Selected NSAIDs

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

The cause of the interaction is not known. When these two medicines are taken together, the nonsteroidal anti-inflammatory medicine may increase the effects of the water pill on your kidney.

What might happen:

This combination may increase the chance for kidney failure or may increase the potassium levels in your blood.

What you should do about this interaction:

Contact your healthcare professionals (e.g., doctor or pharmacist) as soon as possible about taking these two medicines together. If your doctor prescribes these medicines together, it may be necessary to check your kidney function and certain blood levels more often.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.


1.Favre L, Glasson P, Vallotton MB. Reversible acute renal failure from combined triamterene and indomethacin: a study in healthy subjects. Ann Intern Med 1982 Mar;96(3):317-20.

2.McCarthy JT, Torres VE, Romero JC, Wochos DN, Velosa JA. Acute intrinsic renal failure induced by indomethacin: role of prostaglandin synthetase inhibition. Mayo Clin Proc 1982 May;57(5):289-96.

3.Favre L, Glasson P, Riondel A, Vallotton MB. Interaction of diuretics and non-steroidal anti-inflammatory drugs in man. Clin Sci (Lond) 1983 Apr; 64(4):407-15.

4.Weinberg MS, Quigg RJ, Salant DJ, Bernard DB. Anuric renal failure precipitated by indomethacin and triamterene. Nephron 1985;40(2):216-8.

5.Lynn KL, Bailey RR, Swainson CP, Sainsbury R, Low WI. Renal failure with potassium-sparing diuretics. N Z Med J 1985 Aug 14;98(784):629-33.

6.Mathews A, Bailie GR. Acute renal failure and hyperkalemia associated with triamterene and indomethacin. Vet Hum Toxicol 1986 Jun;28(3):224-5.

7.Harkonen M, Ekblom-Kullberg S. Reversible deterioration of renal function after diclofenac in patient receiving triamterene. Br Med J (Clin Res Ed) 1986 Sep 1986;293(6548):698-9.

8.Gehr TWB, Sica DA, Steiger BW, Marshall C. Interaction of triamterene-hydrochlorothiazide (T-H) and ibuprofen (I). Clin Pharmacol Ther 1990 Feb;47(2):200.

9.Glasson P, Vallotton MB. Inhibition of prostaglandins biosynthesis lowers antidiuretic hormone excretion in man. Adv Prostaglandin Thromboxane Res 1980;7:1115-8.

10.Wong DG, Spence JD, Lamki L, Freeman D, McDonald JW. Effect of non-steroidal anti-inflammatory drugs on control of hypertension by beta-blockers and diuretics. Lancet 1986 May 3;1(8488):997-1001.

11.ter Borg EJ, de Jong PE, Meyer S, van Rijswijk MH, Kallenberg CG. Indomethacin and ibuprofen-induced reversible acute renal failure in a patient with systemic lupus erythematosus. Neth J Med 1987 Apr; 30(3-4):181-6.

12.Mor R, Pitlik S, Rosenfeld JB. Indomethacin- and Moduretic--induced hyperkalemia. Isr J Med Sci 1983 Jun;19(6):535-7.

13.Maxzide (triamterene/hydrochlorothiazide) US prescribing information. Lederle January, 2011.

14.Dyazide (triamterene/hydrochlorothiazide) US prescribing information. Glaxo SmithKline February, 2011.

15.Midamor (amiloride) US prescribing information. Merck & Co., Inc. November, 2002.

16.Moduretic (amiloride/hydrochlorothiazide) US prescribing information. Merck & Co., Inc. November, 2002.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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