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Interactions

Zoledronic Acid/Diuretics

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Both of these medicines can affect your kidneys.

What might happen:

Using these medicines together may increase your risk of kidney damage.

What you should do about this interaction:

Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Your doctor may instruct you to drink extra water before and after your zoledronic acid therapy. Your doctor may want to perform blood tests to check your kidney function before and after your zoledronic acid therapy.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

References:

1.Leclerc JM. Dear Canadian Heatlh Care Professional letter: Subject: Association of ACLASTA (zoledronic acid 5 mg/100 mL) solution for intravenous infusion with renal dysfunction. Novartis Pharmaceuticals Canada Inc. October 12, 2010.

2.Reclast (zoledronic acid) US prescribing information. Novartis August, 2011.

3.USFood and Drug Administration. FDA Drug Safety Communication: New contraindication and updated warning on kidney impairment for Reclast (zoledronic acid). available at: http://www.fda.gov/Drugs/DrugSafety/ucm270199.htm September 1, 2011.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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