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Questran

Interactions

Ursodiol/Bile Acid Sequestrants

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Bile acid sequestrants prevent your body from absorbing ursodiol.

What might happen:

The amount of ursodiol in your blood may decrease and it may not work as well.

What you should do about this interaction:

Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Separate the times that you take your ursodiol and your bile acid sequestrant by as much time as possible. Ask your healthcare professional if you have questions about the times you should take your medicines.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

References:

1.Urso (ursodiol) US prescribing information. Aptalis Pharma US, Inc June, 2013.

2.Rust C, Sauter GH, Oswald M, Buttner J, Kullak-Ublick GA, Paumgartner G, Beuers U. Effect of cholestyramine on bile acid pattern and synthesis during administration of ursodeoxycholic acid in man. Eur J Clin Invest 2000 Feb;30(2):135-9.

3.Takikawa H, Ogasawara T, Sato A, Ohashi M, Hasegawa Y, Hojo M. Effect of colestimide on intestinal absorption of ursodeoxycholic acid in men. Int J Clin Pharmacol Ther 2001 Dec;39(12):558-60.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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