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carbidopa-levodopa

Interactions

Levodopa/Protein Interaction

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug, changing your diet or commencing any course of treatment.

Medical warning:

Most important. A change in your diet, medicine, or dosage is likely to be necessary. Promptly consult your doctor or pharmacist.

How the interaction occurs:

When food is taken with levodopa (L-dopa), protein in the food can interfere with absorption of this medicine into your bloodstream. Additionally, high blood levels of protein can interfere with transport of this medicine from your blood into your brain, where the medicine actually works.

What might happen:

The amount of this medicine that reaches your brain can vary depending on how much protein you eat. This may cause changes in your response to this medicine. Your Parkinson's Disease symptoms may reappear or worsen, depending on the amount of protein you eat.

What you should do about this interaction:

It is important to include enough protein in your diet. Do not limit or decrease the amount of protein in your diet without consulting your doctor. In fact, you may be instructed to take this medicine with food to avoid stomach upset (nausea or vomiting).Eat roughly the same amount of protein in your diet from day-to-day to maintain the effectiveness of your medicine. Consult your healthcare professional (e.g., doctor, pharmacist, or dietitian) for any specific instructions on your protein intake, and your overall diet, especially if your symptoms worsen.Your healthcare professionals may be aware of this interaction and may be monitoring you for it. Do not start, stop, or change your medicine or diet before checking with them first.

References:

1.Bianchine JR, Shaw GM. Clinical pharmacokinetics of levodopa in parkinson's disease. Clin Pharmacokinet 1976;1(5):313-38.

2.Morgan JP, Bianchine JR, Spiegel HE, Rivera-Calimlim L, Hersey RM. Metabolism of levodopa in patients with Parkinson's disease. Radioactive and fluorometric assays. Arch Neurol 1971 Jul;25(1):39-44.

3.Nutt JG, Woodward WR, Hammerstad JP, Carter JH, Anderson JL. The "on-off" phenomenon in Parkinson's disease. Relation to levodopa absorption and transport. N Engl J Med 1984 Feb 23;310(8):483-8.

4.Mena I, Cotzias GC. Protein intake and treatment of Parkinson's disease with levodopa. N Engl J Med 1975 Jan 23;292(4):181-4.

5.Gillespie NG, Mena I, Cotzias GC, Bell MA. Diets affecting treatment of parkinsonism with levodopa. J Am Diet Assoc 1973 May;62(5):525-8.

6.Barichella M, Marczewska A, De Notaris R, Vairo A, Baldo C, Mauri A, Savardi C, Pezzoli G. Special low-protein foods ameliorate postprandial off in patients with advanced Parkinson's disease. Mov Disord 2006 Oct; 21(10):1682-7.

7.Simon N, Gantcheva R, Bruguerolle B, Viallet F. The effects of a normal protein diet on levodopa plasma kinetics in advanced Parkinson's disease. Parkinsonism Relat Disord 2004 Mar;10(3):137-42.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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