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Methotrexate (Anti-Rheumatic)

Side Effects

List Methotrexate (Anti-Rheumatic) side effects by likelihood and severity.

The following side effects are associated with Methotrexate (Anti-Rheumatic):

Common side effects of Methotrexate (Anti-Rheumatic):

  • AzotemiaSevere
  • Bacterial Infection of Blood or Tissues affecting the Whole BodySevere
  • Bleeding of the Stomach or IntestinesSevere
  • Canker SoreSevere
  • Decreased Blood PlateletsSevere
  • Decreased White Blood CellsSevere
  • Hole in the IntestineSevere
  • Infection caused by BacteriaSevere
  • Inflammation of the Gums and MouthSevere
  • Inflammation of the Lining of the Stomach and IntestinesSevere
  • Stomach or Intestinal UlcerSevere
  • Sun-Sensitive SkinSevere
  • DizzyLess Severe
  • Feel Like Throwing UpLess Severe
  • Loss of AppetiteLess Severe
  • Low EnergyLess Severe
  • Not Feeling WellLess Severe
  • Throwing UpLess Severe

Infrequent side effects of Methotrexate (Anti-Rheumatic):

  • AnemiaSevere
  • Arachnoid Membrane Inflammation caused by ChemicalsSevere
  • Disease in the White Matter Area of the BrainSevere
  • Hardening of the LiverSevere
  • Hepatitis caused by DrugsSevere
  • Interstitial PneumonitisSevere
  • Liver Tissue DeathSevere
  • Lung FibrosisSevere
  • Abnormal Liver Function TestsLess Severe
  • AcneLess Severe
  • ChillsLess Severe
  • DiarrheaLess Severe
  • FeverLess Severe
  • Hair LossLess Severe
  • ItchingLess Severe
  • Presence of Boils On the SkinLess Severe
  • RashLess Severe
  • Throat IrritationLess Severe

Rare side effects of Methotrexate (Anti-Rheumatic):

  • A Disease Causing Brain Dysfunction - Leigh's DiseaseSevere
  • Acquired Decrease of All Cells in the BloodSevere
  • Acute Liver FailureSevere
  • Avascular Necrosis of BoneSevere
  • Deficiency of Granulocytes a Type of White Blood CellSevere
  • Elevation of Proteins in the UrineSevere
  • Erythema MultiformeSevere
  • Excess Liver Fibrous TissueSevere
  • High Amount of Uric Acid in the BloodSevere
  • Increased Eosinophils in the BloodSevere
  • Increased Spinal Fluid PressureSevere
  • Inflammation of Blood Vessels in the SkinSevere
  • Inflammation of the Alveoli of the LungsSevere
  • Kidney DiseaseSevere
  • Kidney FailureSevere
  • Low Blood Counts due to Bone Marrow FailureSevere
  • Lung Failure causing Loss of BreathSevere
  • Pneumonia caused by Pneumocystis Jirovecii OrganismSevere
  • SeizuresSevere
  • Skin Rash with SloughingSevere
  • Stevens-Johnson SyndromeSevere
  • Toxic Epidermal NecrolysisSevere
  • Bloody UrineLess Severe
  • Inflammation of the BladderLess Severe
  • Low Sperm CountLess Severe

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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