This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Severe. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
When your heart medicine is taken with some antifungal medicines, your liver may process quinidine more slowly.
What might happen:
Your blood levels of your heart medicine may increase. This may cause serious effects on your heart and may affect your hearing.
What you should do about this interaction:
Contact your healthcare professionals (e.g. doctor or pharmacist) as soon as possible about taking these two medicines together. Let your doctor know right away if you experience dizziness, fainting, an irregular heartbeat, or changes in your hearing.They may already be aware of this drug interaction and may be monitoring you for it. Do not stop, start, or change the dosage of any medicine before checking with them first.
1.Diflucan (fluconazole) US prescribing information. Pfizer Inc. November, 2014.
2.Sporanox (itraconazole) US prescribing information. Janssen Pharmaceutica Products, L.P. April, 2015.
3.Nizoral (ketoconazole oral) US prescribing information. Janssen Pharmaceuticals February, 2014.
4.Noxafil (posaconazole) UK summary of product characteristics. Schering-Plough Ltd. February 2, 2006.
5.Noxafil (posaconazole) US prescribing information. Merck & Co. Inc September, 2016.
6.Vfend (voriconazole) US prescribing information. Pfizer Inc. February, 2015.
7.Drew BJ, Ackerman MJ, Funk M, Gibler WB, Kligfield P, Menon V, Philippides GJ, Roden DM, Zareba W. Prevention of torsade de pointes in hospital settings: a scientific statement from the American Heart Association and the American College of Cardiology Foundation. J Am Coll Cardiol 2010 Mar 2;55(9):934-47.
8.Norpace (disopyramide phosphate) US prescribing information. Pfizer Inc. February, 2010.