Severe. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
When these two medicines are taken together, imatinib may cause your body to process the blood-thinner more slowly.
What might happen:
The effect of the blood-thinner may increase.You may experience an increased chance for bleeding including bleeding from your gums, nosebleeds, unusual bruising, or dark stools.
What you should do about this interaction:
Ask your healthcare professionals (e.g. doctor or pharmacist) about taking these medicines together. Your doctor may want to prescribe a different type of blood-thinner for you while you are taking imatinib. If your doctor does prescribe these medicines together, you may need to have bleeding times checked more often. If you have any signs of bleeding, such as bleeding from your gums, nosebleeds, unusual bruising, or dark stools, contact your doctor right away.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.Reference:1.Gleevec (imatinib mesylate) US prescribing information. Novartis Pharmaceuticals Corporation October, 2013.