Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Your seizure medicine may decrease the effects of your metyrapone.
What might happen:
When taking these two medicines together, the results of your metyrapone test may not be accurate.
What you should do about this interaction:
Talk to your healthcare professionals (e.g. doctor or pharmacist) before you have your test. It may be necessary to adjust the dose of the metyrapone used in the test.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
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3.Meikle AW, Jubiz W, Matsukura S, West CD, Tyler FH. Effect of diphenylhydantoin on the metabolism of metyrapone and release of ACTH in man. J Clin Endocrinol Metab 1969 Dec;29(12):1553-8.
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